The biggest difference between LNP formulation platforms is where formulation happens, because that decides how many hands-on steps sit between a lipid library or cargo candidates and a characterized result. LNP screening teams commonly compare the LNP Screening Array with Cytiva NanoAssemblr, Unchained Labs Sunscreen, PreciGenome NanoGenerator, Inside Therapeutics TAMARA, KNAUER NanoScaler Pro, the Dolomite Automated Nanoparticle System, the Elveflow LNP Synthesis Pack, and the Fluigent Liposome Nanoparticle Production Station.

Six of these alternatives are dedicated benchtop instruments and two are pressure-driven kits the lab assembles. Every one of them adds a separate formulation system beside the liquid handler, and the LNP Screening Array is the only platform that formulates on the deck itself.

Formulation rates in the table are the figures each vendor publishes, and the hardware column lists what a lab adds beside its liquid handler to run each platform.

Every alternative formulates on a separate system, so lipid mixes and cargo dilutions are prepared off that system and loaded by hand beforehand, and formulated samples move by hand afterward into post-processing and characterization. Those handoffs repeat for every batch in a screen.

With the LNP Screening Array, the liquid handler prepares lipid mixes and cargo dilutions from reagents on deck, dispenses them into the micromixers, and collects each formulation in its own reservoir. Every formulation finishes on deck, ready for buffer exchange and the team’s downstream characterization, with no recovery step from a separate instrument.

The LNP Screening Array produces each formulation in seconds and reaches 100+ formulations per hour. Each LNP Screening Array holds eight micromixers, and a single run spans as many LNP Screening Arrays as the deck has open positions. At published rates, a 96-formulation screen takes under an hour on the LNP Screening Array and from about 1.5 to nearly 10 hours on the alternatives.

Times are calculated from each vendor’s published formulations per hour. KNAUER, Fluigent, and the NanoGenerator Flex-S do not have published formulation rates. Every alternative also adds a cleaning step, purge, or chip change between formulations or runs. Even when that step is automated, it adds time to every screen, while the LNP Screening Array moves straight to the next formulation.

Many screening teams already run one or more benchtop formulation systems, and adding throughput on any of them means buying another instrument with its own bench space, control software, and setup.

The LNP Screening Array runs on the liquid handler already in the lab, on platforms like Hamilton, Tecan, Opentrons, Formulatrix, and Dynamic Devices. Adding LNP Screening Arrays across open deck positions adds formulations to each run on the automation protocol we configured and installed for that platform.

Talk with our team about the platforms you run or are comparing and the liquid handler in your lab today.